Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

Neutrophils have been classically viewed as a homogenous population. Recently,
neutrophils were phenotypically classified into pro-inflammatory N1 and anti-inflammatory …