Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Drug discovery, development and registration is an expensive and time-consuming process
associated with a high failure rate [Pessetto et al.(Mol Cancer Ther 12: 1299–1309, 2013) …

Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …

Schistosomiasis is a parasitic disease affecting over 200 million people currently treated
with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin …

Peroxiredoxin 2 (Prx2) is a 2-Cys peroxiredoxin extremely abundant in the erythrocyte. The
peroxidase activity was studied in a steady-state approach yielding an apparent KM of 2.4 …

More than 30 years ago, auranofin was developed for the treatment of rheumatoid arthritis
as a substitution for the injectable gold compounds aurothiomalate and aurothioglucose …

There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …

Two major human diseases caused by filariid nematodes are onchocerciasis, or river
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin …

As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to
combat pathogens is an issue of utmost importance. Development of novel and specific …