It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

In the review, current status of sulfoxides on the pharmaceutical market is discussed. In the
first part of the article, natural sulfoxides will be described with a special focus on …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

Enantioselective analytical approaches are essential for monitoring pharmacokinetics and
acquiring accurate data to better understand the role of stereochemistry in …

Cooperative dual catalysis is a powerful strategy for achieving unique reactivity by
combining catalysts with orthogonal modes of action. This approach allows for independent …

This review is in support of the development of selective, precise, fast, and validated
capillary electrophoresis (CE) methods. It follows up a similar article from 1998, Wätzig H …

Abstract Paraoxonase 1 (PON1) can metabolize some compounds such as aromatic
carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide …

Chirality plays a crucial role in drug discovery and development. As a result, a significant
number of commercially available drugs are structurally dissymmetric and enantiomerically …