The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

Global quantification of protein abundances in single cells could provide direct information
on cellular phenotypes and complement transcriptomics measurements. However, single …

Background In high-throughput studies, hundreds to millions of hypotheses are typically
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

Cell type identification is essential for single-cell RNA sequencing (scRNA-seq) studies,
currently transforming the life sciences. CHETAH (CHaracterization of cEll Types Aided by …

Macrophages initiate inflammatory responses via the transcription factor NFκB. The temporal
pattern of NFκB activity determines which genes are expressed and thus, the type of …

In the era of precision medicine, multi-omics approaches enable the integration of data from
diverse omics platforms, providing multi-faceted insight into the interrelation of these omics …

Biological discovery has been driven by advances in throughput and resolution of analysis
technologies. They have also created an indelible bias for snapshot-based knowledge …

Despite the noisy nature of single cells, multicellular organisms robustly generate different
cell types from one zygote. This process involves dynamic cross regulation between …