Delivery of nucleotide sugars to the mammalian Golgi: a very well (un) explained story
D Maszczak-Seneczko, M Wiktor, E Skurska… - International Journal of …, 2022 - mdpi.com
Nucleotide sugars (NSs) serve as substrates for glycosylation reactions. The majority of
these compounds are synthesized in the cytoplasm, whereas glycosylation occurs in the …
these compounds are synthesized in the cytoplasm, whereas glycosylation occurs in the …
[HTML][HTML] Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) …
M Wiktor, W Wiertelak, D Maszczak-Seneczko… - Journal of …, 2021 - Elsevier
Nucleotide sugar transporters (NSTs) are ER and Golgi-resident members of the solute
carrier 35 (SLC35) family which supply substrates for glycosylation by exchanging lumenal …
carrier 35 (SLC35) family which supply substrates for glycosylation by exchanging lumenal …
SLC35A2 Deficiency Promotes an Epithelial-to-Mesenchymal Transition-like Phenotype in Madin–Darby Canine Kidney Cells
M Kot, E Mazurkiewicz, M Wiktor, W Wiertelak… - Cells, 2022 - mdpi.com
In mammalian cells, SLC35A2 delivers UDP–galactose for galactosylation reactions that
take place predominantly in the Golgi lumen. Mutations in the corresponding gene cause a …
take place predominantly in the Golgi lumen. Mutations in the corresponding gene cause a …
Gelsolin traps ribosomal protein SA (RPSA) within lipid nanodomains of the plasma membrane and modulates the level of protein synthesis in the submembranous …
E Mazurkiewicz-Stanek, J Machnik, I Kopernyk… - … et Biophysica Acta (BBA …, 2025 - Elsevier
The connection between the F-actin and ribosome docking to the PM has been reported, but
the exact mechanism has remained unclear. Previously, we discovered that gelsolin (GSN) …
the exact mechanism has remained unclear. Previously, we discovered that gelsolin (GSN) …
Interplay between de novo and salvage pathways of GDP-fucose synthesis
E Skurska, M Olczak - Plos one, 2024 - journals.plos.org
GDP-fucose is synthesised via two pathways: de novo and salvage. The first uses GDP-
mannose as a substrate, and the second uses free fucose. To date, these pathways have …
mannose as a substrate, and the second uses free fucose. To date, these pathways have …
The glycosylation defect in solute carrier SLC35A2/SLC35A3 double knockout cells is rescued by SLC35A2–SLC35A3 and SLC35A3–SLC35A2 hybrids
W Wiertelak, A Pavlovskyi… - FEBS …, 2023 - Wiley Online Library
SLC35A2 and SLC35A3 are homologous proteins with postulated nucleotide sugar
transporting activities. Unlike SLC35A2, whose specificity for UDP‐Gal is well‐established …
transporting activities. Unlike SLC35A2, whose specificity for UDP‐Gal is well‐established …