Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
AL Mahan, KJ Ressler - Trends in neurosciences, 2012 - cell.com
Posttraumatic stress disorder (PTSD) is an anxiety disorder that can develop after a
traumatic experience such as domestic violence, natural disasters or combat-related trauma …
traumatic experience such as domestic violence, natural disasters or combat-related trauma …
A review on human reinstatement studies: an overview and methodological challenges
In human research, studies of return of fear (ROF) phenomena, and reinstatement in
particular, began only a decade ago and recently are more widely used, eg, as outcome …
particular, began only a decade ago and recently are more widely used, eg, as outcome …
Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder
The amygdala is a major structure that orchestrates defensive reactions to environmental
threats and is implicated in hypervigilance and symptoms of heightened arousal in …
threats and is implicated in hypervigilance and symptoms of heightened arousal in …
Brain sites involved in fear memory reconsolidation and extinction of rodents
E Baldi, C Bucherelli - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Fear memory is a motivational system essential for organisms survival having a central role
in organization of defensive behaviors to threat. In the last years there has been a growing …
in organization of defensive behaviors to threat. In the last years there has been a growing …
Common neurocircuitry mediating drug and fear relapse in preclinical models
Background Comorbidity of anxiety disorders, stressor-and trauma-related disorders, and
substance use disorders is extremely common. Moreover, therapies that reduce pathological …
substance use disorders is extremely common. Moreover, therapies that reduce pathological …
Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study …
TB Lonsdorf, J Haaker, R Kalisch - Social cognitive and affective …, 2014 - academic.oup.com
Human context conditioning studies have focused on acquisition and extinction. Subsequent
long-term changes in fear behaviors not only depend on associative learning processes …
long-term changes in fear behaviors not only depend on associative learning processes …
Amount of fear extinction changes its underlying mechanisms
There has been a longstanding debate on whether original fear memory is inhibited or
erased after extinction. One possibility that reconciles this uncertainty is that the inhibition …
erased after extinction. One possibility that reconciles this uncertainty is that the inhibition …
IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway
Z Yang, C Yuan - BMC anesthesiology, 2018 - Springer
Background To investigate the role of IL-17A in the neuroinflammation and cognitive
function of aged rats anaesthetized with sevoflurane through NF-κB pathway. Method The …
function of aged rats anaesthetized with sevoflurane through NF-κB pathway. Method The …
Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders
The burden of anxiety disorders is growing, but the efficacy of available anxiolytic treatments
remains inadequate. Cognitive behavioural therapy for anxiety disorders focuses on …
remains inadequate. Cognitive behavioural therapy for anxiety disorders focuses on …
The role of the basolateral amygdala and infralimbic cortex in (re) learning extinction
NW Lingawi, V Laurent, RF Westbrook… - Psychopharmacology, 2019 - Springer
The basolateral amygdala complex (BLA) and infralimbic region of the prefrontal cortex (IL)
play distinct roles in the extinction of Pavlovian conditioned fear in laboratory rodents. In the …
play distinct roles in the extinction of Pavlovian conditioned fear in laboratory rodents. In the …