Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Candida albicans is a frequent colonizer of human mucosal surfaces as well as an
opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse …

Invasive fungal infections are a leading global cause of human mortality. Only three major
classes of antifungal drugs are widely used, and resistance to all three classes can arise …

Candida albicans is among the most significant human fungal pathogens. However, the vast
majority of C. albicans studies have focused on a single clinical isolate and its marked …

Major Candida albicans virulence traits include its ability to make hyphae, to produce a
biofilm, and to damage host cells. These traits depend upon expression of hypha-associated …

Fungi were some of the earliest organismal systems used to explore mutational processes
and its phenotypic consequences on members of a species. Yeasts that cause significant …

Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to
treatment by all classes of antifungal drugs. Amphotericin B (AmB) is a fungicidal drug that …

RNA interference (RNAi) is a fundamental regulatory pathway with a wide range of
functions, including regulation of gene expression and maintenance of genome stability …

Abstract The WHO Global Status Report on Oral Health 2022 reveals that oral diseases
caused by infection with oral pathogenic microorganisms affect nearly 3.5 billion people …