Monocyte invasion into the retina restricts the regeneration of neurons from Müller glia
N Blasdel, S Bhattacharya, PC Donaldson… - Journal of …, 2024 - jneurosci.org
Endogenous reprogramming of glia into neurogenic progenitors holds great promise for
neuron restoration therapies. Using lessons from regenerative species, we have developed …
neuron restoration therapies. Using lessons from regenerative species, we have developed …
Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells
KS Love, CP Johnstone, EL Peterman, S Gaglione… - …, 2024 - pmc.ncbi.nlm.nih.gov
To realize the potential of engineered cells in therapeutic applications, transgenes must be
expressed within the window of therapeutic efficacy. Differences in copy number and other …
expressed within the window of therapeutic efficacy. Differences in copy number and other …
Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential
KE Galloway - Cellular Reprogramming, 2024 - liebertpub.com
Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells
that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain …
that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain …
Programmable promoter editing for precise control of transgene expression
SR Kabaria, Y Bae, ME Ehmann, AM Beitz… - …, 2024 - pmc.ncbi.nlm.nih.gov
Subtle changes in gene expression direct cells to distinct cellular states. Identifying and
controlling dose-dependent transgenes require tools for precisely titrating expression. To …
controlling dose-dependent transgenes require tools for precisely titrating expression. To …