Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Members of the NSL histone acetyltransferase complex are involved in multiorgan
developmental syndromes. While the NSL complex is known for its importance in early …

Renal injury and the development of albuminuria are tightly connected with the loss of
podocytes. Podocyte damages cause proteinuric renal diseases since podocyte foot …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

Hypertension is a persistent epidemic across the developed world that is closely associated
with kidney disease. Here, we applied a metabolomic, phosphoproteomic, and proteomic …

Background The cell-matrix adhesion between podocytes and the glomerular basement
membrane is essential for the integrity of the kidney's filtration barrier. Despite increasing …

Contractile actomyosin and protrusive branched F-actin networks interact in a dynamic
balance, repeatedly contracting and expanding apical cell contacts to organize the …

Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of
chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a …

Aims Identifying the mechanisms that underlie progression from endothelial damage to
podocyte damage, which leads to massive proteinuria, is an urgent issue that must be …