The human keratins: biology and pathology
R Moll, M Divo, L Langbein - Histochemistry and cell biology, 2008 - Springer
The keratins are the typical intermediate filament proteins of epithelia, showing an
outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing …
outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing …
Detection and clinical importance of micrometastatic disease
Metastatic relapse in patients with solid tumors is caused by systemic preoperative or
perioperative dissemination of tumor cells. The presence of individual tumor cells in bone …
perioperative dissemination of tumor cells. The presence of individual tumor cells in bone …
Significant detection of circulating cancer cells in the blood by reverse transcriptase–polymerase chain reaction during colorectal cancer resection
K Yamaguchi, Y Takagi, S Aoki, M Futamura… - Annals of …, 2000 - journals.lww.com
Significant Detection of Circulating Cancer Cells in the Blo... : Annals of Surgery Significant
Detection of Circulating Cancer Cells in the Blood by Reverse Transcriptase–Polymerase …
Detection of Circulating Cancer Cells in the Blood by Reverse Transcriptase–Polymerase …
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant
T Fehm, A Sagalowsky, E Clifford, P Beitsch… - Clinical cancer …, 2002 - AACR
Purpose: Numerous studies of circulating epithelial cells (CECs) have been described in
cancer patients, and genetic abnormalities have been well documented. However, with one …
cancer patients, and genetic abnormalities have been well documented. However, with one …
Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review
G Peach, C Kim, E Zacharakis, S Purkayastha… - British journal of …, 2010 - nature.com
Background: The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs)
is well understood for patients with stage-I or stage-III disease. Its efficacy for those with …
is well understood for patients with stage-I or stage-III disease. Its efficacy for those with …
Circulating tumor cells and prognosis of patients with resectable colorectal liver metastases or widespread metastatic colorectal cancer: a meta-analysis
B Groot Koerkamp, NN Rahbari, MW Büchler… - Annals of surgical …, 2013 - Springer
Background We performed a systematic review and meta-analysis to investigate the
prognostic value of tumor cells in blood (circulating tumor cells [CTCs]) or bone marrow …
prognostic value of tumor cells in blood (circulating tumor cells [CTCs]) or bone marrow …
Quantification of CK20 gene and protein expression in colorectal cancer by RT‐PCR and immunohistochemistry reveals inter‐and intratumour heterogeneity
S Lassmann, M Bauer, R Soong… - The Journal of …, 2002 - Wiley Online Library
Abstract Cytokeratin 20 (CK20) is an epithelial protein expressed almost exclusively in the
gastrointestinal (GI) tract and is widely used as immunohistochemical marker for routine …
gastrointestinal (GI) tract and is widely used as immunohistochemical marker for routine …
Disseminated single tumor cells as detected by real-time quantitative polymerase chain reaction represent a prognostic factor in patients undergoing surgery for …
U Guller, P Zajac, A Schnider, B Bösch… - Annals of …, 2002 - journals.lww.com
Objective To evaluate the clinical relevance of real-time quantitative polymerase chain
reaction (qPCR) detection of CEA and CK20 transcripts, as potentially related to tumor cell …
reaction (qPCR) detection of CEA and CK20 transcripts, as potentially related to tumor cell …
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients
SA Bustin, VG Gyselman, NS Williams… - British journal of …, 1999 - nature.com
The clinical significance of detecting supposed tumour cell-derived mRNA transcripts in
blood using the polymerase chain reaction (PCR) remains unclear. We have used a fully …
blood using the polymerase chain reaction (PCR) remains unclear. We have used a fully …
Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and …
BM Smith, MJ Slade, J English, H Graham… - Journal of Clinical …, 2000 - ascopubs.org
PURPOSE: We previously developed a quantitative system for the detection of cytokeratin
19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to …
19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to …