Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …

Objective: To assess masitinib in the treatment of ALS. Methods: Double-blind study,
randomly assigning 394 patients (1: 1: 1) to receive riluzole (100 mg/d) plus placebo or …

Background Masitinib is an orally administered tyrosine kinase inhibitor that targets
activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 …

Microglia and peripheral macrophages have both been implicated in amyotrophic lateral
sclerosis (ALS), although their respective roles have yet to be determined. We now show …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary
cause remains elusive, although a combination of different causal factors cannot be ruled …

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

The inflammatory process in the human body is a physiological response involving many
cellular types and mediators. It results in scar formation to separate the damaged area from …

Huntington's disease is associated with a reactive microglial response and consequent
inflammation. To address the role of these cells in disease pathogenesis, we depleted …