Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

We discuss the evolution of OrbitrapTM mass spectrometry (MS) from its birth in the late
1990s to its current role as one of the most prominent techniques for MS. The Orbitrap mass …

Electrospray ionization mass spectrometry (ESI-MS) is nowadays one of the cornerstones of
biomolecular mass spectrometry and proteomics. Advances in sample preparation and …

Protein biopharmaceuticals are macromolecules with a therapeutic effect, commonly
produced by the recombinant DNA technology. They have emerged as important …

Therapeutic monoclonal antibodies (mAbs) are glycoproteins produced by living cell
systems. The glycan moieties attached to the proteins can directly affect protein stability …

The emergence of proteomics has led to major technological advances in mass
spectrometry (MS). These advancements not only benefitted MS‐based high‐throughput …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Altered glycosylation patterns of plasma proteins are associated with autoimmune disorders
and pathogenesis of various cancers. Elucidating glycoprotein microheterogeneity and …

Antibody drug conjugates (ADCs) are macromolecules composed of cytotoxic drugs
covalently attached via a conditionally stable linker to monoclonal antibodies (mAbs). ADCs …

Accurate mass analysis can provide useful information on the stoichiometry and composition
of protein-based particles, such as virus-like assemblies. For applications in nanotechnology …