Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Increasing interest has recently focused on determining whether several natural
compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in …

In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Organophosphorus compounds are extensively used worldwide as pesticides which cause
great hazards to human health. Nerve agents, a subcategory of the organophosphorus …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Organophosphate pesticides (OPs) are used extensively throughout the world. The main
sources of contamination for humans are dietary ingestion and occupational exposures. The …

The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and
PON3. Their physiological role (s) and natural substrates are uncertain. We developed a …

Abstract Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma
high-density lipoprotein (HDL), was the first member of this family of enzymes to be …