Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review
This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
The use of new CRISPR tools in cardiovascular research and medicine
Many novel CRISPR-based genome-editing tools, with a wide variety of applications, have
been developed in the past few years. The original CRISPR–Cas9 system was developed …
been developed in the past few years. The original CRISPR–Cas9 system was developed …
Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity
H Sun, RE Pratt, VJ Dzau, CP Hodgkinson - Journal of Biological Chemistry, 2023 - ASBMB
Directly reprogramming fibroblasts into cardiomyocytes improves cardiac function in the
infarcted heart. However, the low efficacy of this approach hinders clinical applications …
infarcted heart. However, the low efficacy of this approach hinders clinical applications …
MicroRNA-mediated direct reprogramming of human adult fibroblasts toward cardiac phenotype
Modulation of microRNA expression holds the promise to achieve direct reprogramming of
fibroblasts into cardiomyocyte-like cells as a new strategy for myocardial regeneration after …
fibroblasts into cardiomyocyte-like cells as a new strategy for myocardial regeneration after …
[HTML][HTML] Lipoplexes for effective in vitro delivery of microRNAs to adult human cardiac fibroblasts for perspective direct cardiac cell reprogramming
Abstract Design of nanocarriers for efficient miRNA delivery can significantly improve miRNA-
based therapies. Lipoplexes based on helper lipid, dioleoyl phosphatidylethanolamine …
based therapies. Lipoplexes based on helper lipid, dioleoyl phosphatidylethanolamine …
Control of cardiomyocyte differentiation timing by intercellular signaling pathways
M Rowton, A Guzzetta, AB Rydeen… - Seminars in cell & …, 2021 - Elsevier
Abstract Congenital Heart Disease (CHD), malformations of the heart present at birth, is the
most common class of life-threatening birth defect (Hoffman (1995)[1], Gelb (2004)[2], Gelb …
most common class of life-threatening birth defect (Hoffman (1995)[1], Gelb (2004)[2], Gelb …
RNA therapeutics for the cardiovascular system
VJ Dzau, CP Hodgkinson - Circulation, 2024 - Am Heart Assoc
RNA therapeutics hold significant promise in the treatment of cardiovascular diseases.
RNAs are biologically diverse and functionally specific and can be used for gain-or loss-of …
RNAs are biologically diverse and functionally specific and can be used for gain-or loss-of …
Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like …
The present study hypothesizes that the ischemic insults activate epicardial adipose tissue-
derived stem cells (EATDS) to secrete extracellular vesicles (EVs) packed with regenerative …
derived stem cells (EATDS) to secrete extracellular vesicles (EVs) packed with regenerative …
[HTML][HTML] Acute and chronic cardiovascular manifestations of COVID-19: role for endotheliopathy
Abstract SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is
associated with a bewildering array of cardiovascular manifestations, including myocardial …
associated with a bewildering array of cardiovascular manifestations, including myocardial …
[HTML][HTML] Direct Cardiac Reprogramming in the Age of Computational Biology
R Ambroise, P Takasugi, J Liu, L Qian - Journal of Cardiovascular …, 2024 - mdpi.com
Heart disease continues to be one of the most fatal conditions worldwide. This is in part due
to the maladaptive remodeling process by which ischemic cardiac tissue is replaced with a …
to the maladaptive remodeling process by which ischemic cardiac tissue is replaced with a …