Thioamides, which are fascinating isosteres of amides, have garnered significant attention in
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …

Cancer is a significant challenge for effective treatment due to its complex mechanism,
different progressing stages, and lack of adequate procedures for screening and …

In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …

Amino-4, 6-dimethylpyrazolopyridine was applied as a precursor for the synthesis of some
new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives through diazotization …

Cyclin-dependent kinases (CDKs) play essential roles in regulating the cell cycle and are
among the most critical targets for cancer therapy and drug discovery. The primary objective …

Background Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and its
molecular mechanisms are unclear. Nucleolar and spindle-associated protein 1 (NUSAP1) …

This work aimed to prepare multifunctional aptamer-conjugated, photothermally responsive
5-fluorouracil (5fu)-loaded chitosan-bimetallic (Au/Pd) nanoparticles (APT-CS-5fu-Au/Pd …

Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the
current study, a new class of oxazine–and piperazine–linked pyrimidines was developed as …

Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, poses a huge threat to …

Direct synthesis and cytotoxicity activity of new series of pyrido [2, 3-d] pyrimidine was
described. Nicotinamide 2 was synthesized via cyclization of N-cyclohexyl derivative with …