Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

The inability of axons to regenerate after a spinal cord injury in the adult mammalian central
nervous system (CNS) can lead to permanent paralysis. At sites of CNS injury, a glial scar …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Spinal cord and brain injuries lead to complex cellular and molecular interactions within the
central nervous system in an attempt to repair the initial tissue damage. Many studies have …

Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Astrocytes are the most numerous cell type in the central nervous system. They provide
structural, trophic, and metabolic support to neurons and modulate synaptic activity …

The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of
an array of potent antimicrobial peptides by the fat body,. The defence against Gram-positive …

Golgi ranked the peripheral reticulum—which adheres intimately to nerve cell surfaces—
alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At …