Epigenetics and the plasticity of differentiation in normal and cancer stem cells

J Lotem, L Sachs - Oncogene, 2006 - nature.com
Embryonic stem cells are characterized by their differentiation to all cell types during
embryogenesis. In adult life, different tissues also have somatic stem cells, called adult stem …

p53 induced growth arrest versus apoptosis and its modulation by survival cytokines

DA Liebermann, B Hoffman, D Vesely - Cell cycle, 2007 - Taylor & Francis
The p53 tumor suppressor gene encodes for a transcription factor that plays a seminal role
in the responseof mammalian cells to physiological and environmental stress. p53 has been …

Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles

JB Axelsen, J Lotem, L Sachs… - Proceedings of the …, 2007 - National Acad Sciences
We have analyzed gene expression in different normal human tissues and different types of
solid cancers derived from these tissues. The cancers analyzed include brain (astrocytoma …

The GAS41-PP2Cβ complex dephosphorylates p53 at serine 366 and regulates its stability

JH Park, RJ Smith, SY Shieh, RG Roeder - Journal of Biological Chemistry, 2011 - ASBMB
The p53 tumor suppressor is principally regulated by post-translational modifications and
proteasome-dependent degradation. Various kinases have been shown to phosphorylate …

Human cancers overexpress genes that are specific to a variety of normal human tissues

J Lotem, D Netanely, E Domany… - Proceedings of the …, 2005 - National Acad Sciences
We have analyzed gene expression data from three different kinds of samples: normal
human tissues, human cancer cell lines, and leukemic cells from lymphoid and myeloid …

Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells

DL Vesely, B Hoffman, DA Liebermann - Oncogene, 2007 - nature.com
M1 myeloid leukemic cells were used to dissect the molecular mechanisms of myeloid cell
survival and apoptosis. A salient feature of M1 cells is that they respond to the physiological …

Heterogeneity of transcription factor binding specificity models within and across cell lines

M Sharmin, HC Bravo, S Hannenhalli - Genome research, 2016 - genome.cshlp.org
Complex gene expression patterns are mediated by the binding of transcription factors (TFs)
to specific genomic loci. The in vivo occupancy of a TF is, in large part, determined by the …

[PDF][PDF] Gene expression analysis of mesenchymal stem cell differentiation and leukemic over expression of tissue specific genes

D Netanely - Master's thesis, Weissmann Institute of Science …, 2006 - weizmann.ac.il
Firstly, I would like to thank Professor Eytan Domany, my supervisor, for making it all
happen. He is definitely the one to thank for creating an environment that is both fun and …

[图书][B] Investigation of Lipid-Lowering Mechanism of Tamarindus Indica Fruit Pulp in Hepg2 Cells Using Proteomic and Transcriptomic Approaches

UCR Wan - 2014 - search.proquest.com
Abstract Tamarindus indica (T. indica), or tamarind, is an edible fruit widely used in many
applications including culinary, industrial, and medicinal purposes. It has been shown to …

Chapitre 6. Le rôle de l'expression aléatoire des gènes dans la genèse du cancer

JP Capp - Le hasard au cœur de la cellule, 2011 - shs.cairn.info
Chapitre 6. Le rôle de l’expression aléatoire des gènes dans la genèse du cancer | Cairn.info
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