Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

Herein, we use lessons learned in exercise physiology and metabolism to propose that
augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and …

Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor
microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …