[HTML][HTML] Parkinson disease-associated cognitive impairment

D Aarsland, L Batzu, GM Halliday… - Nature Reviews …, 2021 - nature.com
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …

CSF and blood biomarkers for Parkinson's disease

L Parnetti, L Gaetani, P Eusebi, S Paciotti… - The Lancet …, 2019 - thelancet.com
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers
are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical …

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

A Okuzumi, T Hatano, G Matsumoto, S Nojiri, S Ueno… - Nature medicine, 2023 - nature.com
Abnormal α-synuclein aggregation is a key pathological feature of a group of
neurodegenerative diseases known as synucleinopathies, which include Parkinson's …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

NJ Ashton, A Hye, AP Rajkumar, A Leuzy… - Nature Reviews …, 2020 - nature.com
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease

Z Fan, YT Pan, ZY Zhang, H Yang, SY Yu… - Journal of …, 2020 - Springer
Background Emerging evidence indicates that inflammasome-induced inflammation plays a
crucial role in the pathogenesis of Parkinson's disease (PD). Several proteins including α …

Cognition deficits in Parkinson's disease: mechanisms and treatment

C Fang, L Lv, S Mao, H Dong, B Liu - Parkinson's disease, 2020 - Wiley Online Library
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder mainly in middle‐elderly population, which represents diverse nonmotor symptoms …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Parkinson's disease biomarkers based on α‐synuclein

M Fayyad, S Salim, N Majbour, D Erskine… - Journal of …, 2019 - Wiley Online Library
Parkinson's disease is the second most common neurodegenerative disorder after
Alzheimer's disease and is estimated to affect approximately 1–4% of individuals aged over …

Biomarkers for Parkinson's disease: how good are they?

T Li, W Le - Neuroscience bulletin, 2020 - Springer
Parkinson's disease (PD) is a complex neurodegenerative disorder with no cure in sight.
Clinical challenges of the disease include the inability to make a definitive diagnosis at the …