Engineering precision nanoparticles for drug delivery
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …
clinical applications. Nanoparticles have been developed to overcome the limitations of free …
Strategies for non-viral vectors targeting organs beyond the liver
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
Regulating tumor suppressor genes: post-translational modifications
L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
Ionizable lipid nanoparticles for in utero mRNA delivery
RS Riley, MV Kashyap, MM Billingsley, B White… - Science …, 2021 - science.org
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …
mimetics. Salient features include the stability of hybridization complexes (either as …
PTEN-opathies: from biological insights to evidence-based precision medicine
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the
PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN …
PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN …
Spotlight on genetic kidney diseases: A call for drug delivery and nanomedicine solutions
N Trac, A Ashraf, J Giblin, S Prakash, S Mitragotri… - ACS …, 2023 - ACS Publications
Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
Congenital disorders resulting in pathological protein deficiencies are most often treated
postnatally with protein or enzyme replacement therapies. However, treatment of these …
postnatally with protein or enzyme replacement therapies. However, treatment of these …
Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopathies
E Magrin, A Miccio, M Cavazzana - Blood, The Journal of the …, 2019 - ashpublications.org
Abstract β-Thalassemia and sickle cell disease (SCD) are the most prevalent monogenic
diseases. These disorders are caused by quantitative or qualitative defects in the production …
diseases. These disorders are caused by quantitative or qualitative defects in the production …
The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …