Photodynamic therapy (PDT), a treatment for cancer and for certain benign conditions,
utilizes a photosensitizer and light to produce reactive oxygen in cells. PDT is primarily …

В условиях пандемии COVID-19 медицина столкнулась с рядом новых проблем, одной
из которых является постковидный синдром. У многих людей, перенесших COVID-19 …

Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural
functions are increasingly recognized. The machinery of TGF-β signaling, including the …

Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Third Edition
shows the continuity and advancements in our understanding of human life-span …

Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …

Melatonin plays a neuroprotective role in models of neurodegenerative diseases. However,
the molecular mechanisms underlying neuroprotection by melatonin are not well …

Recent evidence suggests that gene expression may be regulated, at least in part, at post‐
transcriptional level by factors inducing the extremely rapid degradation of messenger …

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional
inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional …