Gangliosides in the brain: physiology, pathophysiology and therapeutic applications

S Sipione, J Monyror, D Galleguillos… - Frontiers in …, 2020 - frontiersin.org
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Metabolic dysfunction and oxidative stress in epilepsy

JN Pearson-Smith, M Patel - International Journal of Molecular Sciences, 2017 - mdpi.com
The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

Mechanistic link between vitamin B12 and Alzheimer's disease

AA Lauer, HS Grimm, B Apel, N Golobrodska, L Kruse… - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

Mitochondria, oxidative stress, and temporal lobe epilepsy

S Waldbaum, M Patel - Epilepsy research, 2010 - Elsevier
Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

Anticonvulsant essential oils and their relationship with oxidative stress in epilepsy

DV da Fonsêca, C da Silva Maia Bezerra Filho… - Biomolecules, 2019 - mdpi.com
Epilepsy is a most disabling neurological disorder affecting all age groups. Among the
various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative …

Ganglioside GM1 and the central nervous system

Z Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous
system (CNS). Its expression level, distribution pattern, and lipid composition are dependent …

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

A Bernardo, FE Harrison, M McCord, J Zhao… - Neurobiology of …, 2009 - Elsevier
Gangliosides have been shown to be necessary for β-amyloid (Aβ) binding and
aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b-and c-series …

Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis

K Ryan, DS Backos, P Reigan… - Journal of Neuroscience, 2012 - Soc Neuroscience
Mitochondrial oxidative stress and damage have been implicated in the etiology of temporal
lobe epilepsy, but whether or not they have a functional impact on mitochondrial processes …

Metabolic Regulation of Copper Toxicity during Marine Mussel Embryogenesis

T Young, SL Gale, NLC Ragg, SG Sander, DJ Burritt… - Metabolites, 2023 - mdpi.com
The development of new tools for assessing the health of cultured shellfish larvae is crucial
for aquaculture industries to develop and refine hatchery methodologies. We established a …

Swimming training prevents pentylenetetrazol‐induced inhibition of Na+, K+‐ATPase activity, seizures, and oxidative stress

MA Souza, MS Oliveira, AF Furian, LM Rambo… - …, 2009 - Wiley Online Library
Purpose: In the present study we decided to investigate whether physical exercise protects
against the electrographic, oxidative, and neurochemical alterations induced by …