Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

The base excision repair (BER) glycosylase hOGG1 (human oxoguanine glycosylase 1) is
responsible for repairing oxidative lesions in the genome, in particular oxidised guanine …

DNA repair pathways are tightly regulated processes that recognize specific hallmarks of
DNA damage and coordinate lesion repair through discrete mechanisms, all within the …

The O6-alkylguanine DNA alkyltransferase (AGT) is an important DNA repair protein. AGT
repairs highly mutagenic and cytotoxic alkylguanine lesions that result from metabolic …

Proper chromosome alignment and segregation during mitosis depend on cohesion
between sister chromatids, mediated by the cohesin protein complex, which also plays …

Nuclear poly (ADP-ribose) polymerases 1 and 2 (PARP1 and PARP2) catalyze the synthesis
of poly (ADP-ribose)(PAR) and use NAD+ as a substrate for the polymer synthesis. Both …

Abstract DNMT3A/3L heterotetramers contain two active centers binding CpG sites at 12 bp
distance, however their interaction with DNA not containing this feature is unclear. Using …

Improper maintenance of the mitochondrial genome progressively disrupts cellular
respiration and causes severe metabolic disorders commonly termed mitochondrial …

Recognition and removal of DNA damages is essential for cellular and organismal viability.
Nucleotide excision repair (NER) is the sole mechanism in humans for the repair of …

We developed a simple method for producing arrays of stretchable DNAs, called DNA
garden, for single-molecule fluorescence measurements. The method is based on …