The BLAST programs are widely used tools for searching protein and DNA databases for
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …

A wide variety of work in social science concerns sequences of events or phenomena. This
essay reviews concepts of sequence and methods for analyzing sequences. After a brief …

A substantial fraction of disease-causing mutations are pathogenic through aberrant
splicing. Although genome profiling studies have identified somatic single-nucleotide …

The sensitivity of the commonly used progressive multiple sequence alignment method has
been greatly improved for the alignment of divergent protein sequences. Firstly, individual …

Background In a previous paper, we introduced MUSCLE, a new program for creating
multiple alignments of protein sequences, giving a brief summary of the algorithm and …

We describe a new method (T-Coffee) for multiple sequence alignment that provides a
dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most …

The algorithm described in this paper discovers one or more motifs in a collection of DNA or
protein sequences by using the technique of expectation maximization to fit a two …

PlantCARE is a database of plant cis-acting regulatory elements, enhancers and repressors.
Regulatory elements are represented by positional matrices, consensus sequences and …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

Probabilistic models are becoming increasingly important in analysing the huge amount of
data being produced by large-scale DNA-sequencing efforts such as the Human Genome …