Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines

O Verho, JE Bäckvall - Journal of the American Chemical …, 2015 - ACS Publications
Chemoenzymatic dynamic kinetic resolution (DKR) constitutes a convenient and efficient
method to access enantiomerically pure alcohol and amine derivatives. This Perspective …

Lipases: Valuable catalysts for dynamic kinetic resolutions

AS de Miranda, LSM Miranda, ROMA de Souza - Biotechnology Advances, 2015 - Elsevier
Dynamic kinetic resolutions have proven to be a useful method for the preparation of
enantiopure compounds from racemates, leading to the formation of a single enantiomer in …

Orchestration of Concurrent Oxidation and Reduction Cycles for Stereoinversion and Deracemisation of sec-Alcohols

CV Voss, CC Gruber, K Faber, T Knaus… - Journal of the …, 2008 - ACS Publications
Black and white are opposites as are oxidation and reduction. Performing an oxidation, for
example, of a sec-alcohol and a reduction of the corresponding ketone in the same vessel …

Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope

Q Wu, P Soni, MT Reetz - Journal of the American Chemical …, 2013 - ACS Publications
Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in
academic and industrial laboratories with many different kinds of applications. In fine …

Chemoenzymatic dynamic kinetic resolution of alcohols and amines

JH Lee, K Han, MJ Kim, J Park - European Journal of Organic …, 2010 - Wiley Online Library
Dynamic kinetic resolution (DKR) is an attractive process for the transformation of racemic
mixtures into optically active compounds. For successful DKR, efficient racemization is …

Dynamic Kinetic Resolution via Hydrolase‐Metal Combo Catalysis in Stereoselective Synthesis of Bioactive Compounds

P Hoyos, V Pace, AR Alcantara - Advanced Synthesis & …, 2012 - Wiley Online Library
The development of new and more economically and environmentally attractive processes
to afford chiral molecules is still an open challenge in organic synthesis. During last years …

Stereochemical editing: Catalytic racemization of secondary alcohols and amines

J Zhang, Z Zheng, C Zhu - Chinese Chemical Letters, 2024 - Elsevier
Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,
agrochemicals, and food additives. Dynamic kinetic resolution (DKR) is an efficient strategy …

Markovnikov Wacker‐Tsuji Oxidation of Allyl (hetero) arenes and Application in a One‐Pot Photo‐Metal‐Biocatalytic Approach to Enantioenriched Amines and …

J Albarrán‐Velo, V Gotor‐Fernández… - … Synthesis & Catalysis, 2021 - Wiley Online Library
Abstract The Wacker‐Tsuji aerobic oxidation of various allyl (hetero) arenes under
photocatalytic conditions to form the corresponding methyl ketones is presented. By using a …

Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols

K Wang, W Wang, D Lou, J Zhang, C Chi… - ACS Central …, 2024 - ACS Publications
Chemoenzymatic dynamic kinetic resolution (DKR), combining a metal racemization catalyst
with an enzyme, has emerged as an elegant solution to transform racemic substrates into …

Ionic‐Surfactant‐Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

H Kim, YK Choi, J Lee, E Lee, J Park… - Angewandte Chemie …, 2011 - Wiley Online Library
Dynamic kinetic resolution (DKR) is among the most practical methods for the transformation
of racemates to single enantiomers.[1] DKR can provide high yields and excellent …