Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …

Uterine fibroids are the commonest benign tumours of women and affect all races with a
cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy …

Fluorination is commonly employed to optimize bioactivity and pharmaco-kinetic properties
of drug candidates. Aliphatic fluorination often reduces the lipophilicity (log P), but …

ABSTRACT Introduction Uterine fibroids (UFs) are the most common benign tumor arising
from myometrium of reproductive age women, with significant financial burden estimated in …

Uterine fibroids (UFs, AKA leiomyoma) are the most important benign neoplastic threat to
women's health, with costs up to hundreds of billions of health care dollars worldwide …

Introduction: To-date, the only cure for symptomatic uterine fibroids (UFs) is surgical
intervention. However, surgery may eliminate the hope of future pregnancies; moreover, the …

Uterine fibroids (leiomyomas or myomas) are the most frequent benign tumors in women.
Heavy menstrual bleeding with resultant anemia, dysmenorrhea, chronic pelvic pain …

Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …

Introduction Uterine fibroids are the most common benign gynecological tumors affecting
women of reproductive ages. Although surgery is the definitive treatment choice, several …

Abnormal uterine bleeding (AUB) is a chronic, debilitating and common condition affecting
one in four women of reproductive age. Current treatments (conservative, medical and …