High-throughput screening technology in industrial biotechnology

W Zeng, L Guo, S Xu, J Chen, J Zhou - Trends in biotechnology, 2020 - cell.com
Based on the development of automatic devices and rapid assay methods, various high-
throughput screening (HTS) strategies have been established for improving the performance …

[HTML][HTML] Controlled droplet microfluidic systems for multistep chemical and biological assays

TS Kaminski, P Garstecki - Chemical Society Reviews, 2017 - pubs.rsc.org
Droplet microfluidics is a relatively new and rapidly evolving field of science focused on
studying the hydrodynamics and properties of biphasic flows at the microscale, and on the …

Light-driven eco-evolutionary dynamics in a synthetic replicator system

K Liu, A Blokhuis, C van Ewijk, A Kiani, J Wu… - Nature Chemistry, 2024 - nature.com
Darwinian evolution involves the inheritance and selection of variations in reproducing
entities. Selection can be based on, among others, interactions with the environment …

[HTML][HTML] Synthetic microbial communities

T Großkopf, OS Soyer - Current opinion in microbiology, 2014 - Elsevier
Highlights•Microbial interactions and system function are two ways to study
communities.•Natural microbial communities are difficult to define and to study.•Synthetic …

Microfluidics for cell-based high throughput screening platforms—A review

G Du, Q Fang, JMJ den Toonder - Analytica chimica acta, 2016 - Elsevier
In the last decades, the basic techniques of microfluidics for the study of cells such as cell
culture, cell separation, and cell lysis, have been well developed. Based on cell handling …

[HTML][HTML] Droplet microfluidics for microbiology: techniques, applications and challenges

TS Kaminski, O Scheler, P Garstecki - Lab on a Chip, 2016 - pubs.rsc.org
Droplet microfluidics has rapidly emerged as one of the key technologies opening up new
experimental possibilities in microbiology. The ability to generate, manipulate and monitor …

Bacterial growth: a statistical physicist's guide

RJ Allen, B Waclaw - Reports on Progress in Physics, 2018 - iopscience.iop.org
Bacterial growth presents many beautiful phenomena that pose new theoretical challenges
to statistical physicists, and are also amenable to laboratory experimentation. This review …

Droplet microfluidics for high-throughput analysis of antibiotic susceptibility in bacterial cells and populations

W Postek, P Garstecki - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Antibiotic-resistant bacteria are an increasing concern both in everyday life and
specialized environments such as healthcare. As the rate of antibiotic-resistant infections …

[HTML][HTML] One drop at a time: toward droplet microfluidics as a versatile tool for single-cell analysis

A Rakszewska, J Tel, V Chokkalingam, WTS Huck - NPG Asia Materials, 2014 - nature.com
Miniaturization has been the key driver for many remarkable technological developments in
recent decades. Miniaturization has now also extended into biology, thereby setting the …

Artificial intelligence-accelerated high-throughput screening of antibiotic combinations on a microfluidic combinatorial droplet system

D Yang, Z Yu, M Zheng, W Yang, Z Liu, J Zhou… - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic platforms have been employed as an effective tool for drug screening and
exhibit the advantages of lower reagent consumption, higher throughput and a higher …