Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Breast cancer is the most frequent malignancy in women worldwide, and triple-negative
breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The …

Tumor acidosis promotes disease progression through a stimulation of fatty acid (FA)
metabolism in cancer cells. Instead of blocking the use of FAs by acidic cancer cells, we …

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel
disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is …

Tumours depend on nutrients supplied by the host for their growth and survival.
Modifications to the host's diet can change nutrient availability in the tumour …

Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …

Pyroptosis is a type of regulated cell death executed by gasdermin family members.
However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear …

D-mannose is a monosaccharide approximately a hundred times less abundant than
glucose in human blood. Previous studies demonstrated that supraphysiological levels of D …

Objectives Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐
mannose shows therapeutic value in many inflammatory conditions. Here, we investigated …