DNA methylation pathways and their crosstalk with histone methylation
J Du, LM Johnson, SE Jacobsen… - Nature reviews Molecular …, 2015 - nature.com
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
The cell proliferation antigen Ki-67 organises heterochromatin
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely
used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 …
used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells
The use of two kinase inhibitors (2i) enables derivation of mouse embryonic stem cells
(ESCs) in the pluripotent ground state. Using whole-genome bisulfite sequencing (WGBS) …
(ESCs) in the pluripotent ground state. Using whole-genome bisulfite sequencing (WGBS) …
H3K9 methyltransferase G9a and the related molecule GLP
Y Shinkai, M Tachibana - Genes & development, 2011 - genesdev.cshlp.org
The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
H Hashimoto, Y Liu, AK Upadhyay… - Nucleic acids …, 2012 - academic.oup.com
Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5‐
methylcytosine (M; 5mC) and 5‐hydroxymethylcytosine (H; 5hmC). During semi …
methylcytosine (M; 5mC) and 5‐hydroxymethylcytosine (H; 5hmC). During semi …
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
M Saitou, S Kagiwada, K Kurimoto - Development, 2012 - journals.biologists.com
Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9
X Liu, Q Gao, P Li, Q Zhao, J Zhang, J Li… - Nature …, 2013 - nature.com
Epigenetic inheritance of DNA methylation in mammals requires a multifunctional protein
UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique hemi …
UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique hemi …