After decades of research, the mechanism of action of lithium in preventing recurrences of
bipolar disorder remains only partially understood. Lithium research is complicated by the …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

Introduction: Disruptions in sleep and circadian rhythms are observed in individuals with
bipolar disorders (BD), both during acute mood episodes and remission. Such abnormalities …

Mood disorders, including bipolar disorder and depression, are relatively common human
diseases for which pharmacological treatment options are often not optimal. Among existing …

Bipolar disorder (BD) is a severe and common psychiatric disorder. BD pathogenesis,
clinical manifestations and relapses are associated with numerous circadian rhythm …

The use of lithium is a cornerstone for preventing recurrences in bipolar disorder (BD). The
response of patients with bipolar disorder to lithium has different levels of magnitude. About …

Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD)
suggested novel risk genes. However, only few of them were followed up and further, the …

Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and
daily activity that often normalize after lithium treatment in responsive patients. As lithium is …

Mood stabilizers form a cornerstone in the long-term treatment of bipolar disorder. The first
representative of their family was lithium, still considered a prototype drug for the prevention …

Aims: Bipolar disorder (BD) is a lifelong psychiatric illness characterized by manic and
depressive episodes affecting 1–5% of the general population. Among mood-stabilizing …