[HTML][HTML] Epigenetic control and manipulation of neuronal maturation timing
During brain development, the sequence of developmental steps and the underlying
transcriptional regulatory logic are largely conserved across species. However, the temporal …
transcriptional regulatory logic are largely conserved across species. However, the temporal …
Rational design of small-sized peptidomimetic inhibitors disrupting protein–protein interaction
J Wang, P Zheng, J Yu, X Yang, J Zhang - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Protein-protein interactions are fundamental to nearly all biological processes. Due to their
structural flexibility, peptides have emerged as promising candidates for developing …
structural flexibility, peptides have emerged as promising candidates for developing …
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA …
A Izzo, I Akol, A Villarreal, S Lebel… - Epigenetics & …, 2023 - Springer
Background NPM1 is a phosphoprotein highly abundant in the nucleolus. However,
additional nuclear functions have been attributed to NPM1, probably through interaction with …
additional nuclear functions have been attributed to NPM1, probably through interaction with …
Male-specific behavioral and transcriptomic changes in aging C. elegans neurons
Aging is a complex biological process with sexually dimorphic aspects. Although cognitive
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
[HTML][HTML] Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Cell metabolism is a key regulator of human neocortex development and evolution. Several
lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism …
lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism …
Chromatin Environment-Dependent Effects of DOT1L on Gene Expression in Male Germ Cells
M Coulee, A de la Iglesia, M Blanco, C Gobe… - bioRxiv, 2024 - biorxiv.org
The H3K79 methyltransferase DOT1L is essential for multiple aspects of mammalian
development where it has been shown to regulate gene expression. Here, by producing and …
development where it has been shown to regulate gene expression. Here, by producing and …
Male-specific features of C. elegans neuronal aging
Aging is a complex biological process, with sexually dimorphic aspects. For example, men
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …