Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue

I Khan, A Ibrar, W Ahmed, A Saeed - European journal of medicinal …, 2015 - Elsevier
The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …

Acceptorless dehydrogenative coupling reactions with alcohols over heterogeneous catalysts

SMAH Siddiki, T Toyao, K Shimizu - Green Chemistry, 2018 - pubs.rsc.org
Heterogeneous catalysis for the one-pot synthesis of added-value chemicals is a growing
area in green chemistry. Among various types of organic transformations that are accessible …

One-Pot Cascade Synthesis of Quinazolin-4(3H)-ones via Nickel-Catalyzed Dehydrogenative Coupling of o-Aminobenzamides with Alcohols

S Parua, S Das, R Sikari, S Sinha… - The Journal of Organic …, 2017 - ACS Publications
In this paper, we report a general, efficient, and environmentally benign method for the one-
pot cascade synthesis of quinazolin-4 (3 H)-ones via acceptorless dehydrogenative …

A nickel catalyzed acceptorless dehydrogenative approach to quinolines

S Parua, R Sikari, S Sinha, S Das… - Organic & …, 2018 - pubs.rsc.org
A general, efficient and environmentally benign, one-step synthesis of substituted quinoline
derivatives was achieved by acceptorless dehydrogenative coupling of o …

Synthesis of N‐Heterocycles via Oxidant‐Free Dehydrocyclization of Alcohols Using Heterogeneous Catalysts

K Sun, H Shan, GP Lu, C Cai, M Beller - Angewandte Chemie, 2021 - Wiley Online Library
N‐Heterocycles, such as pyrroles, pyrimidines, quinazolines, and quinoxalines, are
important building blocks for organic chemistry and the fine‐chemical industry. For their …

Synthesis of quinazoline and quinazolinone derivatives via ligand-promoted ruthenium-catalyzed dehydrogenative and deaminative coupling reaction of 2 …

PT Kirinde Arachchige, CS Yi - Organic letters, 2019 - ACS Publications
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the
dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form …

Advanced synthetic strategies for constructing quinazolinone scaffolds

RS Rohokale, UA Kshirsagar - Synthesis, 2016 - thieme-connect.com
Quinazolinones are important heterocyclic scaffolds because of their broad spectrum of
medicinal and pharmacological properties. The development of advanced synthetic …

Synthesis of 2-aryl quinazolinones via iron-catalyzed cross-dehydrogenative coupling (CDC) between N–H and C–H bonds

Y Jang, SB Lee, J Hong, S Chun, J Lee… - Organic & Biomolecular …, 2020 - pubs.rsc.org
Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative
coupling between methyl arenes and anthranilamides. The C–H functionalization of the …

Linear-organic-polymer-supported iridium complex as a recyclable auto-tandem catalyst for the synthesis of quinazolinones via selective hydration/acceptorless …

S Hao, J Yang, P Liu, J Xu, C Yang, F Li - Organic Letters, 2021 - ACS Publications
A linear-organic-polymer-supported iridium complex Cp* Ir@ P4VP, which is designed and
synthesized by the coordinative immobilization of [Cp* IrCl2] 2 on poly (4-vinylpyridine), was …

Ru doped hydrotalcite catalyzed borrowing hydrogen-mediated N-alkylation of benzamides, sulfonamides, and dehydrogenative synthesis of quinazolinones

B Sardar, R Jamatia, A Samanta… - The Journal of Organic …, 2022 - ACS Publications
An efficient Ru doped hydrotalcite catalyzed N-alkylation of benzamides and sulfonamides
with alcohols via borrowing hydrogen catalysis is illustrated. Various primary alcohols …