New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Round, round we go–strategies for enzymatic cofactor regeneration

S Mordhorst, JN Andexer - Natural product reports, 2020 - pubs.rsc.org
Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

Bioinformatic atlas of radical SAM enzyme-modified RiPP natural products reveals an isoleucine–tryptophan crosslink

KA Clark, MR Seyedsayamdost - Journal of the American …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

Enzymatic cascade reactions in biosynthesis

CT Walsh, BS Moore - Angewandte Chemie International …, 2019 - Wiley Online Library
Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

β-NAD as a building block in natural product biosynthesis

L Barra, T Awakawa, K Shirai, Z Hu, G Bashiri, I Abe - Nature, 2021 - nature.com
Abstratct β-Nicotinamide adenine dinucleotide (β-NAD) is a pivotal metabolite for all living
organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of …

Green rust: the simple organizing 'seed'of all life?

MJ Russell - Life, 2018 - mdpi.com
Korenaga and coworkers presented evidence to suggest that the Earth's mantle was dry and
water filled the ocean to twice its present volume 4.3 billion years ago. Carbon dioxide was …

The hidden enzymology of bacterial natural product biosynthesis

TA Scott, J Piel - Nature Reviews Chemistry, 2019 - nature.com
Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog

R Méheust, CJ Castelle, PB Matheus Carnevali… - The ISME …, 2020 - academic.oup.com
Currently described members of Elusimicrobia, a relatively recently defined phylum, are
animal-associated and rely on fermentation. However, free-living Elusimicrobia have been …

Metabolic functions of the human gut microbiota: the role of metalloenzymes

LJ Rajakovich, EP Balskus - Natural product reports, 2019 - pubs.rsc.org
Covering: up to the end of 2017 The human body is composed of an equal number of
human and microbial cells. While the microbial community inhabiting the human …

RaS-RiPPs in Streptococci and the human microbiome

KA Clark, LB Bushin… - ACS bio & med Chem …, 2022 - ACS Publications
Radical S-adenosylmethionine (RaS) enzymes have quickly advanced to one of the most
abundant and versatile enzyme superfamilies known. Their chemistry is predicated upon …