Metabolically versatile free-living bacteria have global regulation systems that allow cells to
selectively assimilate a preferred compound among a mixture of several potential carbon …

SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

The bacterium Pseudomonas aeruginosa is especially pathogenic, often being associated
with intractable pneumonia and high mortality. How P. aeruginosa avoids immune clearance …

Our understanding of bacterial pathogenesis is dominated by the cell biology of the host–
pathogen interaction. However, the majority of metabolites that are used in prokaryotic and …

It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

The long-term persistance of P. aeruginosa in the cystic fibrosis (CF) lung is characterized
by the selection of a variety of genotypes and phenotypes that typically descend from one …

The opportunistic pathogen Pseudomonas aeruginosa undergoes genetic change during
chronic airway infection of cystic fibrosis (CF) patients. One common change is a mutation …

Pseudomonas putida KT2440 has received increasing attention as an important biocatalyst
for the conversion of diverse carbon sources to multiple products, including the olefinic …

In addition to transcriptome and proteome studies, metabolome analysis represents a third
complementary approach to identify metabolic pathways and adaptation processes. In order …

Pseudomonas aeruginosa is the leading pathogen of chronic cystic fibrosis (CF) lung
infection. Life-long persistance of P. aeruginosa in the CF lung requires a sophisticated …