FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sajini - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Genetic polymorphisms associated with obesity in the Arab world: a systematic review

S Younes, A Ibrahim, R Al-Jurf, H Zayed - International Journal of …, 2021 - nature.com
Background Obesity, one of the most common chronic health conditions worldwide, is a
multifactorial disease caused by complex genetic and environmental interactions. Several …

Comprehensive analysis of N6-methyladenosine RNA methylation regulators expression identify distinct molecular subtypes of myocardial infarction

X Shi, Y Cao, X Zhang, C Gu, F Liang, J Xue… - Frontiers in Cell and …, 2021 - frontiersin.org
Background: Myocardial infarction (MI) is one of the leading threats to human health. N6-
methyladenosine (m6A) modification, as a pivotal regulator of messenger RNA stability …

Ramadan diurnal intermittent fasting is associated with attenuated FTO gene expression in subjects with overweight and obesity: a prospective cohort study

MI Madkour, LJB Malhab, WM Abdel-Rahman… - Frontiers in …, 2022 - frontiersin.org
Aim and Background A growing body of evidence supports the impact of intermittent fasting
(IF) on normalizing body weight and that the interaction between body genes and …

Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients

AS Boiko, IV Pozhidaev, DZ Paderina… - Pharmacogenomics …, 2021 - Taylor & Francis
Purpose Metabolic syndrome (MetS) is characterized by abdominal obesity,
hyperglycaemia, dyslipidaemia and hypertension. FTO gene has been implicated in the …

Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine

A Sabarneh, S Ereqat, S Cauchi, O AbuShamma… - BMC medical …, 2018 - Springer
Background Genetic and environmental factors play a crucial role in the development of type
2 diabetes mellitus (T2DM) and obesity. This study aimed to investigate the association of …

The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population

M Saber-Ayad, S Manzoor, H Radwan… - PLoS …, 2019 - journals.plos.org
Background The risk of obesity is determined by complex interactions between genetic and
environmental factors. Little research to date has investigated the interaction between gene …

Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates

SEH Chehadeh, W Osman, S Nazar, L Jerman… - Gene, 2020 - Elsevier
Objective Overweight and obesity are major risk factors for Type 2 Diabetes Mellitus (T2DM),
cardiovascular disease (CVD) and cancer. Genetic predisposition has been shown to play a …

[HTML][HTML] Advances in biomedical applications of vitamin D for VDR targeted management of obesity and cancer

VK Gupta, L Sahu, S Sonwal, A Suneetha… - Biomedicine & …, 2024 - Elsevier
Abstract Background 1, 25 (OH) 2 D 3 is a fat-soluble vitamin, involved in regulating Ca 2+
homeostasis in the body. Its storage in adipose tissue depends on the fat content of the …

A comprehensive insight into the potential roles of VDR gene polymorphism in obesity: a systematic review

AH Faghfouri, E Faghfuri, V Maleki… - … of physiology and …, 2022 - Taylor & Francis
Vitamin D receptor (VDR) gene polymorphisms are believed to be involved in the obesity
pathogenesis. This study summarises the results of research concerning the association …