The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …

Proteasomes are the central proteolytic machines that are critical for breaking down most of
the damaged and abnormal proteins in human cells. Although universally applicable drugs …

Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We
investigated the role of Wnt signaling in maintaining the BRB by limiting transcytosis. Mice …

The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Abstract Major Facilitator Superfamily Domain containing 2 A (MFSD2A) is a transporter that
is highly enriched at the blood-brain and blood-retinal barriers, where it mediates Na+ …