[HTML][HTML] The role of inspiratory flow in selection and use of inhaled therapy for patients with chronic obstructive pulmonary disease

DA Mahler - Respiratory Medicine, 2020 - Elsevier
Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management,
and inhaler selection can have a profound impact on drug delivery and medication …

Lung deposition and inspiratory flow rate in patients with chronic obstructive pulmonary disease using different inhalation devices: a systematic literature review and …

A Baloira, A Abad, A Fuster… - … Journal of Chronic …, 2021 - Taylor & Francis
Background Our aim was to describe: 1) lung deposition and inspiratory flow rate; 2) main
characteristics of inhaler devices in chronic obstructive pulmonary disease (COPD) …

Comparison of peak inspiratory flow rate via the Breezhaler®, Ellipta® and HandiHaler® dry powder inhalers in patients with moderate to very severe COPD: a …

P Altman, L Wehbe, J Dederichs, T Guerin… - BMC pulmonary …, 2018 - Springer
Background The chronic and progressive nature of chronic obstructive pulmonary disease
(COPD) requires self-administration of inhaled medication. Dry powder inhalers (DPIs) are …

A review of upper airway physiology relevant to the delivery and deposition of inhalation aerosols

T Mekonnen, X Cai, C Burchell, H Gholizadeh… - Advanced Drug Delivery …, 2022 - Elsevier
Developing effective oral inhaled drug delivery treatment strategies for respiratory diseases
necessitates a thorough knowledge of the respiratory system physiology, such as the …

Numerical study on the effect of the realistic mouth-inhaler positions on orally inhaled drug delivery in pediatric intersubject upper airways

X Zhou, Y Li, H Miao, Y Zhang, A Yu, F Huang, R Li… - Powder Technology, 2024 - Elsevier
The relative position between the pediatric upper airway and the inhalation device during
real inhalation administration has significant effects on the delivery efficiency of orally …

Measuring peak inspiratory flow in patients with chronic obstructive pulmonary disease

JA Ohar, GT Ferguson, DA Mahler… - … journal of chronic …, 2022 - Taylor & Francis
Dry powder inhalers (DPIs) are breath actuated, and patients using DPIs need to generate
an optimal inspiratory flow during the inhalation maneuver for effective drug delivery to the …

Inhaler technique in asthma and COPD: challenges and unmet knowledge that can contribute to suboptimal use in real life

AS Melani - Expert Review of Clinical Pharmacology, 2021 - Taylor & Francis
Introduction: Inhalers are the most commonly used devices for lung drug delivery in asthma
and COPD. Inhaler use offers several advantages but requires the user's proper mastery …

State-of-the-art review of the application and development of various methods of aerosol therapy

M Matuszak, M Ochowiak, S Włodarczak… - International Journal of …, 2022 - Elsevier
Aerosol therapy is a rapidly developing field of science. Due to a number of advantages, the
administration of drugs to the body with the use of aerosol therapy is becoming more and …

Combining experimental and computational techniques to understand and improve dry powder inhalers

V Chaugule, CY Wong, K Inthavong… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Dry Powder Inhalers (DPIs) continue to be developed to deliver an
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …

Potential effects of inhaler mouthpiece size on particle deposition in the human upper airway

X Cai, B Ma, A Kourmatzis, F Salehi, A Lee… - Aerosol Science and …, 2022 - Taylor & Francis
Understanding the impact of inhaler mouthpiece sizes on particle transport and deposition in
the human upper airway is important to optimize inhaler designs toward improving the …