The microtubule-based kinesin motors and actin-based myosin motors generate motions
associated with intracellular trafficking, cell division, and muscle contraction. Early studies …

Site-directed spin labeling of proteins is experiencing a phase of rapid technical evolution,
application and evaluation. New strategies have been introduced for determining membrane …

Optical trapping technology now allows investigators in the motility field to measure the
forces generated by single motor molecules. A handful of research groups have exploited …

A new method is described for measuring motions of protein domains in their native
environment on the physiological timescale. Pairs of cysteines are introduced into the …

This is the second in a series of canonical reviews on invertebrate muscle. We cover here
thin and thick filament structure, the molecular basis of force generation and its regulation …

▪ Abstract Molecular machines are tiny energy conversion devices on the molecular-size
scale. Whether naturally occurring or synthetic, these machines are generally more efficient …

Mechanically-interlocked molecules (MIMs) are at the basis of artificial molecular machines
and are attracting increasing interest for various applications, from catalysis to drug delivery …

We tested the hypothesis that low specific tension (force/cross-sectional area) in skeletal
muscle from aged animals results from structural changes in myosin that occur with aging …

Molecular motors such as kinesin and myosin often work in groups to generate the directed
movements and forces critical for many biological processes. Although much is known about …

To better understand how skeletal muscle myosin molecules move actin filaments, we
determine the motion-generating biochemistry of a single myosin molecule and study how it …