Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

The most visible and, until very recently, the only hypothesis regarding the involvement of
microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that …

Recently, apoptosis has been implicated in the selective neuronal loss of Alzheimer's
disease (AD). Apoptosis is regulated by the B cell leukemia-2 gene product (Bcl-2) family …

Objective. While the causes of neuronal death in Parkinson's disease (PD) and other
neurodegenerative disorders are still unknown, several mechanisms are under discussion …

The family of B-cell lymphoma-2 (Bcl-2) proteins exerts key functions in cellular health. Bcl-2
primarily acts in mitochondria where it controls the initiation of apoptosis. However, during …

Objective: To address the role of cell death regulatory genes of the bcl-2 and caspase
families in the neuropathology of human epilepsy using tissue extracted from patients …

Background Microglial-mediated neuroinflammation is a key factor underlying the
pathogenesis of various neurodegenerative diseases and also an important target for the …

Microglia play a major role in the cellular response associated with the pathological lesions
of Alzheimer's disease. As brain-resident macrophages, microglia elaborate and operate …

Mitochondria play a central role in cellular physiology. Besides their classic function of
energy metabolism, mitochondria are involved in multiple cell functions, including energy …