[HTML][HTML] Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities
E O'Reilly, HA Zeinabad, E Szegezdi - Blood Reviews, 2021 - Elsevier
Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …
Drug resistance mechanisms of acute myeloid leukemia stem cells
J Niu, D Peng, L Liu - Frontiers in Oncology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury
X Huang, X Zhang, N Machireddy, CE Evans… - Science translational …, 2023 - science.org
Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Faithful genome integrity maintenance plays an essential role in cell survival. Here, we
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex–mediated DNA replication
YTHDC1 has distinct functions as a nuclear N 6-methyladenosine (m6A) reader in
regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid …
regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid …
Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening
C Zhou, M Kuang, Y Tao, J Wang, Y Luo, Y Fu, Z Chen… - Cell Stem Cell, 2024 - cell.com
Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our
research identifies the transcription factor Nynrin as a crucial regulator of HSC maintenance …
research identifies the transcription factor Nynrin as a crucial regulator of HSC maintenance …
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …
non-transcriptional functions in various biological processes critical for cellular homeostasis …
FOXM1 regulates glycolysis and energy production in multiple myeloma
The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural
history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory …
history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory …
FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
FOXM1, a known transcription factor, promotes cell proliferation in a variety of cancer cells.
Here we show that Foxm1 is required for survival, quiescence and self-renewal of MLL-AF9 …
Here we show that Foxm1 is required for survival, quiescence and self-renewal of MLL-AF9 …