[HTML][HTML] The human transcription factors
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …
transcription, forming a complex system that guides expression of the genome. Despite keen …
Transcription factor–DNA binding: beyond binding site motifs
S Inukai, KH Kock, ML Bulyk - Current opinion in genetics & development, 2017 - Elsevier
Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
[HTML][HTML] Transcription factors activate genes through the phase-separation capacity of their activation domains
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
Impact of cytosine methylation on DNA binding specificities of human transcription factors
INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …
PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants
With the goal of providing a comprehensive, high-quality resource for both plant transcription
factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF …
factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF …
PlantPAN3. 0: a new and updated resource for reconstructing transcriptional regulatory networks from ChIP-seq experiments in plants
CN Chow, TY Lee, YC Hung, GZ Li… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Plant Promoter Analysis Navigator (PlantPAN; http://PlantPAN. itps. ncku. edu.
tw/) is an effective resource for predicting regulatory elements and reconstructing …
tw/) is an effective resource for predicting regulatory elements and reconstructing …
Short tandem repeats bind transcription factors to tune eukaryotic gene expression
CA Horton, AM Alexandari, MGB Hayes, E Marklund… - Science, 2023 - science.org
Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
The epigenetic landscape of T cell exhaustion
Exhausted T cells in cancer and chronic viral infection express distinctive patterns of genes,
including sustained expression of programmed cell death protein 1 (PD-1). However, the …
including sustained expression of programmed cell death protein 1 (PD-1). However, the …
[HTML][HTML] DNA methylation predicts age and provides insight into exceptional longevity of bats
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
SEdb 2.0: a comprehensive super-enhancer database of human and mouse
Y Wang, C Song, J Zhao, Y Zhang, X Zhao… - Nucleic Acids …, 2023 - academic.oup.com
Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …