The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family
F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19
T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …
[HTML][HTML] Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases
T Tanaka, T Kishimoto - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …
contributes to host defense against acute environmental stress, while dysregulated …
Impact of infectious and inflammatory disease on cytochrome P450–mediated drug metabolism and pharmacokinetics
ET Morgan - Clinical Pharmacology & Therapeutics, 2009 - Wiley Online Library
Infection and inflammation are associated with downregulation of hepatic and extrahepatic
cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review …
cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review …
[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Regulation of drug-metabolizing enzymes and transporters in inflammation
AE Aitken, TA Richardson… - Annu. Rev. Pharmacol …, 2006 - annualreviews.org
▪ Abstract Inflammation and infection have long been known to downregulate the activity and
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
Therapeutic targeting of the interleukin-6 receptor
T Tanaka, M Narazaki… - Annual review of …, 2012 - annualreviews.org
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It
contributes to host defense against pathogens, but dysregulation of IL-6 production plays a …
contributes to host defense against pathogens, but dysregulation of IL-6 production plays a …
Hepatotoxicity of decabromodiphenyl ethane (DBDPE) and decabromodiphenyl ether (BDE-209) in 28-day exposed Sprague-Dawley rats
Y Sun, Y Wang, B Liang, T Chen, D Zheng… - Science of the Total …, 2020 - Elsevier
Abstract Decabromodiphenyl ether (BDE-209) and its substitute decabromodiphenyl ethane
(DBDPE) are heavily used in various industrial products as flame retardant. They have been …
(DBDPE) are heavily used in various industrial products as flame retardant. They have been …