Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …

Osteosarcoma (OS) is a highly aggressive pediatric cancer, characterized by frequent lung
metastasis and pathologic bone destruction. Vascular endothelial growth factor A (VEGFA) …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …

The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front
of a number of human carcinomas. We have investigated podoplanin function in cultured …

Members of the ezrin–radixin–moesin (ERM) family of proteins are involved in multiple
aspects of cell migration by acting both as crosslinkers between the membrane, receptors …

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or
young adults. It is the second highest cause of cancer-related death in these age groups …

Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic
biology and clinical management of cancer over the past 30 years. These contributions have …

Traditional prognostic determinants in osteosarcoma have included demographics (age,
sex), tumour size, site, stage, and the response to chemotherapy. Many of these are …