PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

A Nakamura, S Sakai, Y Taketomi, J Tsuyama, Y Miki… - Neuron, 2023 - cell.com
The brain is generally resistant to regeneration after damage. The cerebral endogenous
mechanisms triggering brain self-recovery have remained unclarified to date. We here …

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

Z Su, Z Wang, S Lindtner, L Yang, Z Shang… - …, 2022 - journals.biologists.com
The striatum is a central regulator of behavior and motor function through the actions of D1
and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …

A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease

L Tang, N Xu, M Huang, W Yi, X Sang, M Shao… - Nature …, 2023 - nature.com
The degenerative process in Parkinson's disease (PD) causes a progressive loss of
dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in …

The Principle of Cortical Development and Evolution

Z Yang - Neuroscience bulletin, 2024 - Springer
Human's robust cognitive abilities, including creativity and language, are made possible, at
least in large part, by evolutionary changes made to the cerebral cortex. This paper reviews …

In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1, 2-Diacetylbenzene …

HD Nguyen, WH Jo, NHM Hoang, MS Kim - Neurotoxicology, 2022 - Elsevier
We aimed to identify the molecular mechanisms through which prolactin protects against 1,
2-Diacetylbenzene (DAB)-induced memory and motor impairments. The gene expression …

The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade

HN Tran, QH Nguyen, J Jeong, DL Loi… - Cell Death & …, 2023 - nature.com
At the top of the midbrain is the inferior colliculus (IC), which functions as the major hub for
processing auditory information. Despite the functional significance of neurons in the IC, our …

The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice

HM Hoffmann, JD Meadows, JA Breuer… - Journal of …, 2021 - Wiley Online Library
The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior
homeobox 1 (Vax1) are required for brain development. Their expression in specific brain …

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement

N Khandelwal, A Kulkarni, NI Ahmed, M Harper… - Science …, 2024 - science.org
Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable
for striatal development, providing the foundation for motor and cognitive functions. Despite …

Molecular Landscape of Tourette's Disorder

J Widomska, W De Witte, JK Buitelaar… - International Journal of …, 2023 - mdpi.com
Tourette's disorder (TD) is a highly heritable childhood-onset neurodevelopmental disorder
and is caused by a complex interplay of multiple genetic and environmental factors. Yet, the …

RLS-associated MEIS transcription factors control distinct processes in human neural stem cells

V Kittke, C Zhao, DD Lam, P Harrer, W Krezel… - Scientific Reports, 2024 - nature.com
MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for
developmental processes in a wide range of tissues, including the brain. They can execute …