Z Su, Z Wang, S Lindtner, L Yang, Z Shang… - …, 2022 - journals.biologists.com
The striatum is a central regulator of behavior and motor function through the actions of D1 and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …
L Tang, N Xu, M Huang, W Yi, X Sang, M Shao… - Nature …, 2023 - nature.com
The degenerative process in Parkinson's disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in …
Human's robust cognitive abilities, including creativity and language, are made possible, at least in large part, by evolutionary changes made to the cerebral cortex. This paper reviews …
HD Nguyen, WH Jo, NHM Hoang, MS Kim - Neurotoxicology, 2022 - Elsevier
We aimed to identify the molecular mechanisms through which prolactin protects against 1, 2-Diacetylbenzene (DAB)-induced memory and motor impairments. The gene expression …
At the top of the midbrain is the inferior colliculus (IC), which functions as the major hub for processing auditory information. Despite the functional significance of neurons in the IC, our …
HM Hoffmann, JD Meadows, JA Breuer… - Journal of …, 2021 - Wiley Online Library
The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior homeobox 1 (Vax1) are required for brain development. Their expression in specific brain …
Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable for striatal development, providing the foundation for motor and cognitive functions. Despite …
J Widomska, W De Witte, JK Buitelaar… - International Journal of …, 2023 - mdpi.com
Tourette's disorder (TD) is a highly heritable childhood-onset neurodevelopmental disorder and is caused by a complex interplay of multiple genetic and environmental factors. Yet, the …
V Kittke, C Zhao, DD Lam, P Harrer, W Krezel… - Scientific Reports, 2024 - nature.com
MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for developmental processes in a wide range of tissues, including the brain. They can execute …