Clinical relevance of tumour-associated macrophages

MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Microglial signatures and their role in health and disease

O Butovsky, HL Weiner - Nature Reviews Neuroscience, 2018 - nature.com
Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy

B Zhao, H Li, Y Xia, Y Wang, Y Wang, Y Shi… - Journal of Hematology & …, 2022 - Springer
Immunotherapy for cancer is a rapidly developing treatment that modifies the immune
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …

TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia

FL Yeh, Y Wang, I Tom, LC Gonzalez, M Sheng - Neuron, 2016 - cell.com
Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are
associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray …

Clusterin in Alzheimer's disease: mechanisms, genetics, and lessons from other pathologies

EM Foster, A Dangla-Valls, S Lovestone… - Frontiers in …, 2019 - frontiersin.org
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Mechanisms of Aβ clearance and degradation by glial cells

M Ries, M Sastre - Frontiers in aging neuroscience, 2016 - frontiersin.org
Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

The role of platelets in inflammation

MR Thomas, RF Storey - Thrombosis and haemostasis, 2015 - thieme-connect.com
There is growing recognition of the critical role of platelets in inflammation and immune
responses. Recent studies have indicated that antiplatelet medications may reduce mortality …

TREM2 in neurodegenerative diseases

TR Jay, VE von Saucken, GE Landreth - Molecular neurodegeneration, 2017 - Springer
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

TREM2, microglia, and neurodegenerative diseases

FL Yeh, DV Hansen, M Sheng - Trends in molecular medicine, 2017 - cell.com
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of
death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β …

sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

M Suárez‐Calvet, G Kleinberger… - EMBO molecular …, 2016 - embopress.org
TREM 2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐
function mutations of TREM 2 are associated with increased risk of Alzheimer's disease …