Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic …

Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the
gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy …

Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant
CD8+ tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from …

Colitis has become a major health concern worldwide. The objective of the present study
was to determine the probiotic influence of different strains of B. pseudolongum (Bp7 and …

From the very beginning of the discipline of microbiology, the dogma has been to isolate
bacteria in pure culture in order to be able to define their individual properties. This process …

BACKGROUND & AIMS: Goblet cells (GC) facilitate mucosal protection and epithelial barrier
repair, yet the innate immune mechanisms that selectively drive GC functions have not been …

Inflammatory bowel disease (IBD) results from intestinal epithelial barrier defect and
dysregulated mucosal immune response. This study aimed to evaluate the therapeutic …

TNF plays a crucial role in the pathogenesis of Crohn disease. Dysregulated TNF production
in mice that bear the genetic deletion of the TNF AU-rich regulatory elements …

The central nervous system and gastrointestinal tract form the primary targets of
chemotherapy-induced toxicities. Symptoms associated with damage to these regions have …

Interleukin-33 (IL-33) is a novel member of the IL-1 cytokine family. It has been shown to
elicit a Th2-like cytokine response in immunocompetent cells through binding and activation …