Epigenetics of aging and aging-associated diseases

D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

AA Parkhitko, P Jouandin, SE Mohr, N Perrimon - Aging cell, 2019 - Wiley Online Library
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

New insights into the role of histone changes in aging

SJ Yi, K Kim - International Journal of Molecular Sciences, 2020 - mdpi.com
Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …

Histone modifications as an intersection between diet and longevity

D Molina-Serrano, D Kyriakou, A Kirmizis - Frontiers in genetics, 2019 - frontiersin.org
Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

B Ayuda-Durán, S González-Manzano… - Molecules, 2020 - mdpi.com
The nematode Caenorhabditis elegans was introduced as a model organism in biological
research by Sydney Brenner in the 1970s. Since then, it has been increasingly used for …

Flavonoids from the mung bean coat promote longevity and fitness in Caenorhabditis elegans

M Tao, R Li, T Xu, Z Zhang, T Wu, S Pan, X Xu - Food & Function, 2021 - pubs.rsc.org
Mung beans possess health benefits related to their bioactive ingredients, mainly flavonoids,
which are highly concentrated in the coat. However, the anti-aging effects of mung beans …

[HTML][HTML] A 4.7-kDa polysaccharide from Panax ginseng suppresses Aβ pathology via mitophagy activation in cross-species Alzheimer's disease models

S Zhang, F Liu, J Li, C Jing, J Lu, X Chen… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurological condition that progresses with age. Amyloid-β
(Aβ) aggregation has been suggested to be a key pathogenic process in Alzheimer's …

Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110

Y Chen, L Su, C Huang, S Wu, X Qiu, X Zhao, Q Meng… - Cancer Letters, 2021 - Elsevier
Aberrant glycosylation in pancreatic cancer has been linked to cancer development,
progression and chemoresistance. However, the role of glycogene, such as …

Nuclear organization in stress and aging

R Romero-Bueno, PC Ruiz, M Artal-Sanz, P Askjaer… - Cells, 2019 - mdpi.com
The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by
the nuclear envelope, which plays a prominent role in the structural organization of the cell …

Cannabidivarin alleviates α‐synuclein aggregation via DAF‐16 in Caenorhabditis elegans

F Wang, T Jin, H Li, H Long, Y Liu, S Jin… - The FASEB …, 2023 - Wiley Online Library
Cannabidivarin (CBDV), a structural analog of cannabidiol (CBD), has received attention in
recent years owing to its anticonvulsant property and potential for treating autism spectrum …