Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Background & Aims Increased de novo lipogenesis creates excess intrahepatic fat and
lipotoxins, propagating liver damage in nonalcoholic steatohepatitis. TVB-2640, a fatty acid …

In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …

Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …