Primary CNS lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma that is
typically confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic …

Programmed cell death protein 1 (PD-1) blockade targeting the PD-1 immune checkpoint
has demonstrated unprecedented clinical efficacy in the treatment of advanced cancers …

In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …

Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous
malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without …

Purpose Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-
Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate. In cHL …

Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR)
signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets BCR signaling and is …

Primary central nervous system (CNS) lymphoma (PCNSL) and primary testicular lymphoma
(PTL) are rare extranodal large B-cell lymphomas with similar genetic signatures. There are …

Characterizing the tumor immune microenvironment enables the identification of new
prognostic and predictive biomarkers, the development of novel therapeutic targets and …