Single-strand break end resection in genome integrity: mechanism and regulation by APE2
DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
[HTML][HTML] Xenopus egg extract: A powerful tool to study genome maintenance mechanisms
WS Hoogenboom, DK Douwel, P Knipscheer - Developmental biology, 2017 - Elsevier
DNA repair pathways are crucial to maintain the integrity of our genome and prevent genetic
diseases such as cancer. There are many different types of DNA damage and specific DNA …
diseases such as cancer. There are many different types of DNA damage and specific DNA …
APE1 senses DNA single-strand breaks for repair and signaling
DNA single-strand breaks (SSBs) represent the most abundant type of DNA damage.
Unrepaired SSBs impair DNA replication and transcription, leading to cancer and …
Unrepaired SSBs impair DNA replication and transcription, leading to cancer and …
APE1 recruits ATRIP to ssDNA in an RPA-dependent and-independent manner to promote the ATR DNA damage response
Cells have evolved the DNA damage response (DDR) pathways in response to DNA
replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed …
replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed …
APE2 promotes DNA damage response pathway from a single-strand break
Y Lin, L Bai, S Cupello, MA Hossain… - Nucleic acids …, 2018 - academic.oup.com
As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily
repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired …
repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired …
A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage
The DNA glycosylase NEIL3 has been implicated in DNA repair pathways including the
base excision repair and the interstrand cross-link repair pathways via its DNA glycosylase …
base excision repair and the interstrand cross-link repair pathways via its DNA glycosylase …
Integrative biology of native cell extracts: a new era for structural characterization of life processes
FL Kyrilis, A Meister, PL Kastritis - Biological Chemistry, 2019 - degruyter.com
Advances in electron microscopy have provided unprecedented access to the structural
characterization of large, flexible and heterogeneous complexes. Until recently, cryo …
characterization of large, flexible and heterogeneous complexes. Until recently, cryo …
[PDF][PDF] APE2: catalytic function and synthetic lethality draw attention as a cancer therapy target
Abstract AP endonuclease 2 (APE2, APEX2 or APN2) is an emerging critical protein
involved in genome and epigenome integrity. Whereas its catalytic function as a nuclease in …
involved in genome and epigenome integrity. Whereas its catalytic function as a nuclease in …
Function and molecular mechanisms of APE2 in genome and epigenome integrity
APE2 is a rising vital player in the maintenance of genome and epigenome integrity. In the
past several years, a series of studies have shown the critical roles and functions of APE2 …
past several years, a series of studies have shown the critical roles and functions of APE2 …
APE2 is a general regulator of the ATR-Chk1 DNA damage response pathway to maintain genome integrity in pancreatic cancer cells
The maintenance of genome integrity and fidelity is vital for the proper function and survival
of all organisms. Recent studies have revealed that APE2 is required to activate an ATR …
of all organisms. Recent studies have revealed that APE2 is required to activate an ATR …